ProductDescription:
Relaxin2isapeptidehormonestructurallyrelatedtoinsulin,whichisexpressedintheplacenta,decidua,prostate,andovariesduringpregnancy.Ofthethreeknownrelaxingenes,Relaxin2istheonlyrelaxinknowntocirculateintheblood.Relaxin2bindsspecificallytotheLGR7andLGR8receptors,previouslyidentifiedas“orphan”Gprotein-coupledreceptors.SignalingbyRelaxin2throughitstargetreceptorsenhancesthegrowthofpubicligaments,andtheripeningofthecervixduringbirth.RecombinantHumanRelaxin2isanon-glycosylated,6.0kDa,disulfide-linked,heterodimericproteinconsistingofa24aminoacidA-chain,anda29aminoacidB-chain.
TechnicalSpecifications:
- Species:Human
- Expression:E.coliCellExpressed
- Purity:≥98%
- Endotoxin:<1.0EU/μg
- MolecularMass:6.0kDa
- CountryofOrigin:USA
PurityConfirmation:
ThiswasdeterminedbySDS-PAGEgelandHPLCanalysis.
AASequence:
alphaSubunit:
QLYSALANKC | CHVGCTKRSL | ARFC |
betaSubunit:
DSWMEEVIKL | CGRELVRAQI | AICGMSTWS |
ReconstitutionBuffer:
Centrifugethevialpriortoopening.Reconstituteinwatertoaconcentrationof0.1-1.0mg/ml.Donotvortex.
Storage:
Forextendedstorage,itisrecommendedtofurtherdiluteinabuffercontainingacarrierprotein(example0.1%HSA)andstoreinworkingaliquotsat-20°Cto-80°C.